Jimmy Garoppolo rolled his ankle and couldn't finish the game with a high-ankle sprain. Tevin Coleman and Raheem Mostert both left the game.

Javon Kinlaw enjoyed an encouraging debut for the San Francisco 49ers, with his play a bright spot in a surprise season-opening defeat to...

The San Francisco 49ers dropped the season opener on Sunday vs. Arizona Cardinals, while struggling in three key phases of the game.

Digging into some final thoughts on who the 2020 San Francisco 49ers are before Week 1 kicks off.

Robert Saleh's dominant unit seemed to struggle when facing athletic, mobile quarterbacks who could evade the 49ers' defensive line.

The linebacker position is going to be extremely important as the 49ers look to contain Kyler Murray in Week 1.

Fast forward three seasons and the slogan this season is going to be Faithful To The Bay, to celebrate the region's oldest team.

As the 49ers have dealt with a rash of injuries at wide receiver, opportunity could be there for a rejuvenated Dante Pettis.

The 49ers will attempt go ahead and trim their rosters down from 80 to 53 on Saturday, as they prepare for Week 1 of the regular season.

Another critical thing to know when it comes to pass protection and the run game is how to identify the middle linebacker (mike). When th...